- Association of CD57+ Natural Killer Cells with Better Overall Survival in DLBCL Patients.
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Jeong Hyeon Lee, Yoon Jin Kwak, Chul Hwan Kim, Insun Kim
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Korean J Pathol. 2011;45(4):361-370.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.361
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 Abstract
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- BACKGROUND
Malignant tumor cells may evoke the innate and adaptive immune systems. Various immune cells are involved in this immune reaction, and tumor infiltrating lymphocytes, macrophages, natural killer (NK) cells are associated with patient prognosis for solid tumors.
METHODS
Seventy-eight patients who were diagnosed with diffuse large B cell lymphoma (DLBCL) between 2001 and 2009 were selected. CD57+ NK cells, CD68+ tumor associated macrophages (TAMs), and CD4+ and CD8+ T cells were evaluated in tissue sections using immunohistochemical staining and compared with clinical parameters including age, gender, performance status, clinical stage, serum lactic dehydrogenase level, number of extranodal sites, international prognostic index score, chemotherapy response, and survival.
RESULTS
Patients with high numbers of CD57+ NK cells had a significantly higher overall survival rate than patients with low numbers of CD57+ NK cells. However, no significant difference was observed between the number of CD57+ NK cells and other prognostic parameters. The number of CD68+ TAMs and CD4+ or CD8+ T cells was not significantly correlated with prognostic factors in patients with DLBCL.
CONCLUSIONS
An evaluation of tumor infiltrating CD57+ NK cells is recommended as a prognostic indicator in patients with DLBCL.
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Citations
Citations to this article as recorded by  - The prognostic value of tumor-associated macrophages detected by immunostaining in diffuse large B cell lymphoma: A meta-analysis
Mei Lin, Shupei Ma, Lingling Sun, Zhiqiang Qin
Frontiers in Oncology.2023;[Epub] CrossRef
- Immunohistochemical Identification of Pneumocystis jirovecii in Liquid-based Cytology of Bronchoalveolar Lavage: Nine Cases Report.
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Jeong Hyeon Lee, Ji Young Lee, Mi Ran Shin, Hyeong Kee Ahn, Chul Whan Kim, Insun Kim
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Korean J Pathol. 2011;45(1):115-118.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.115
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3,366
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- Pneumocystis pneumonia (PCP) is caused by the yeast-like fungus Pneumocystis jirovecii, which is specific to humans.
PCP could be a source of opportunistic infection in adults that are immunosuppressed and children with prematurity or malnutrition. The diagnosis should be confirmed by identification of the causative organism, by analysis of the sputum, a bronchoalveolar lavage or a tissue biopsy. In both histologic and cytologic specimens, the cysts are contained within frothy exudates, which form aggregated clumps. The cysts often collapse forming crescent-shaped bodies that resemble ping-pong balls. We recently diagnosed nine cases of PCP using an immunohistochemical stain for Pneumocystis.
The patients consisted of five human immunodeficiency virus positive individuals, two renal transplant recipients, and two patients with a malignant disease. All nine patients were infected with P. jirovecii, which was positive for monoclonal antibody 3F6. In conclusion, the immunohistochemical stain used in this report is a new technique for the detection of P. jirovecii infection.
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Citations
Citations to this article as recorded by - Metabolic Changes in Serum Metabolome of Beagle Dogs Fed Black Ginseng
Dahye Yoon, Ye Jin Kim, Wan Kyu Lee, Bo Ram Choi, Seon Min Oh, Young Seob Lee, Jae Kwang Kim, Dae Young Lee
Metabolites.2020; 10(12): 517. CrossRef - Effects of Red or Black Ginseng Extract in a Rat Model of Inflammatory Temporomandibular Joint Pain
Hyeon-Jeong Lee, Yun-Kyung Kim, Ja-Hyeong Choi, Jung-Hwa Lee, Hye-Jin Kim, Mi-Gyung Seong, Min-Kyung Lee
Journal of Dental Hygiene Science.2017; 17(1): 65. CrossRef - Value of Bronchoalveolar Lavage Fluid Cytology in the Diagnosis ofPneumocystis jiroveciiPneumonia: A Review of 30 Cases
Ji-Youn Sung, Joungho Han, Young Lyun Oh, Gee Young Suh, Kyeongman Jeon, Taeeun Kim
Tuberculosis and Respiratory Diseases.2011; 71(5): 322. CrossRef
- Effect of Selective Cyclooxygenase 2 Inhibitor in TCDD Pre-exposed Thyroid Papillary Carcinoma Cell Line.
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Hae Sung Kim, Kwang Sung Ahn, Jeong Hyeon Lee, Yang Seok Chae, Nam Hee Won, Jong Sang Choi, Chul Hwan Kim
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Korean J Pathol. 2011;45(1):1-8.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.1
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3,110
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Abstract
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- BACKGROUND
Cyclooxygenase 2 (COX-2) is related to carcinogenesis and progression of cancer. COX-2 has been detected in thyroid cancer. This suggests that COX-2 inhibitor may be useful to control the growth of thyroid cancer cells as well as the progression of thyroid cancer.
Tetrachlorodibenzodioxin (TCDD), acting as an inflammatory cytokine, directly induces the expression of COX-2. We examine whether TCDD controls the effect of COX-2 inhibitor on thyroid cancer cells.
METHODS
The effects of TCDD and celecoxib on thyroid papillary carcinoma cell line (SNU790) were examined using cell proliferation and fluorescence-activated cell sorting analysis. Western blot analysis was performed to determine the expressed COX-2 levels and the cell cycle-related proteins. The matrix metalloproteinase-2 (MMP-2) expression and gelatinolytic activity were examined using real time-polymerase chain reaction and zymography.
RESULTS
TCDD directly induced the growth of SNU790 and the expression of cyclin D1, cyclin A, cyclin E, p21 and COX-2.
Celecoxib suppressed the growth of SNU790 and the expression of cyclin D1 and cyclin E. Celecoxib reduced the MMP-2 expression and the gelatinolytic activity, but those effects were decreased in the SNU790 by either pre-treatment with TCDD or co-treatment with TCDD and celecoxib.
CONCLUSIONS
Celocoxib effect is directly reduced depending on the exposure to TCDD. TCDD exposure should be considered in the treatment with Celecoxib.
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Citations
Citations to this article as recorded by - Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective1This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.
Shannon Healy, Protiti Khan, Shihua He, James R. Davie
Biochemistry and Cell Biology.2012; 90(1): 39. CrossRef
- Hepatoid Thymic Carcinoma: A Case Report.
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Jeong Hyeon Lee, Hyunchul Kim, Yang Seok Chae, Nam Hee Won, Jong Sang Choi, Chul Hwan Kim
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Korean J Pathol. 2009;43(6):562-565.
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DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.562
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- We report here on a rare case of hepatoid thymic carcinoma in a 34-year-old man. The patient complained of a high fever and headache, and a 6.6cm-sized anterior mediastinal mass was found on chest computed tomography (CT). There was no hepatic mass seen on abdominal CT. The resected mass consisted of epithelioid cells with abundant eosinophilic cytoplasm, pleomorphic vesicular nuclei and prominent nucleoli, and the mass was surrounded by thymic tissue. The tumor cells were immunopositive for cytokeratin 7, alpha-1-antitrypsin, hepatocyte staining, and epithelial membrane antigen, but they were negative for CD5, alpha-fetoprotein (AFP) and placental alkaline phosphatase, and this all led to a diagnosis of hepatoid thymic carcinoma rather than hepatoid yolk sac tumor. This entity should be included in the differential diagnosis of epithelioid thymic tumors.
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